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Muscle wasting, poor muscle tone, and weakness As a therapy for people with HIV, tesamorelin plays double duty as a countermeasure against another common symptom of the disease: wasting.15 Defined in part as the loss of more than 10% of a person’s body weight, HIV-associated wasting is thought to stem from various aspects of HIV infection and treatment — low appetite, altered metabolism, poor nutrient absorption, opportunistic infections, depression, drug side effects, and inflammation.16 It’s a serious consequence but one that can be mitigated