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Mechanistically, it was revealed that glutamine uptake effectively increased the concentration of tumor glutamine and its downstream metabolite α-KG, which drove hypomethylation of H3K4me3 via JmjC-containing KDMs, resulting in the downregulation of epigenetically activated oncogenic pathways [89]
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(2) FCHIP Budget Neutrality Methodology and Analytical Approach As explained in the FY 2022 IPPS/LTCH PPS final rule, we finalized a policy to address the demonstration budget neutrality methodology and analytical approach for the initial period of the demonstration
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