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Food allergen-mediated IgE cross-linking could increase the numbers or responsiveness of MCs expressing NK-1, and their activation by substance P could lead to exacerbation of IBS

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Certain groups should exercise particular caution or avoid BPC-157 entirely: individuals with active cancer or significant cancer history, pregnant or breastfeeding women (no safety data exists), those taking blood thinners (potential interaction effects), and anyone with autoimmune conditions affecting connective tissue