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5-HT: 5-hydroxytryptamine 5-HTP: 5-hydroxytryptophan 5-MT: 5-methoxytryptamine 5-MTP: 5-methoxytryptophan AKI: acute kidney injury ArAT: aromatic amino acid aminotransferase AHR: aryl hydrocarbon receptor AA-NAT: arylal kylamine N-acetyltransferase CRF: chronic renal failure COX-2: cyclooxygenase-2 ESRD: end-stage renal disease eGFR: estimated glomerular filtration rate FOXO: fork head box HIOMT: hydroxyindole-O-methyltransferase IAA: indole-3-acetic acid IAld: indole-3-aldehyde ILA: indole-3-lactic acid IPA: indole-3-propionic acid IDO: indoleamine 2,3-dioxygenase ILDH: indolelactic acid dehydrogenase IS: indoxyl sulfate IBD: inflammatory bowel disease IκB: inhibitor of kappa B IIS: insulin/insulin-like growth factor IBS: irritable bowel syndrome Keap1: kelch-like ECH-associated protein 1 mTOR: mammalian target of rapamycin N-acetyl-5-HT: N-acetyl-5-hydroxytryptamine NAD+: nicotinamide adenine dinucleotide Nrf2: nuclear factor erythroid 2-related factor 2 NF-κB: nuclear factor kappa B SERT: serotonin-selective reuptake transporter TDO: tryptophan 2,3-dioxygenase TPH1: tryptophan hydroxylase 1 TPH2: tryptophan hydroxylase 2 TnaA: tryptophanase UUO: unilateral ureteral obstruction This study was supported by National Natural Science Foundation of China (Nos

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02 Wo wird Glutathion gebildet