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Furthermore, in mild-to-moderate asthmatics with airflow limitation, low plasma selenium concentrations were also associated with greater lipid peroxidation byproducts, increased concentrations of high-sensitivity C-reactive protein, and an increased ratio of CD4+/CD8+ lymphocytes, suggesting a shift in Th2 polarization (124)
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Nevertheless, a few challenges have been observed in explaining the complete mechanism that contributes to the effectiveness of probiotics in depression, including the heterogeneity of depression and the gut microbiota’s complexity
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