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By binding to the melanocortin 1 receptor (MC1R) with high affinity, it activates the melanin synthesis pathway, stimulates residual melanocytes to produce melanin, and helps the skin form physiological pigmentation

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Of note, SLC25A45 is highly expressed in the mouse kidney, where single-nuclei RNA-seq data ( 32 ) identified that epithelial cells of the proximal tubules and collecting ducts express Slc25a45 and carnitine synthesis enzymes, including Tmlhe and Aldh9a1 ( Fig